Endocrine Abstracts

Prolactinomas are the most common secreting pituitary tumors. Although most respond well to dopamine agonists, some prolactinomas are dopamine-resistant and very aggressive. Here we present a 37-year-old patient with aggressive prolactinoma.Case report: The 37-year-old patient was referred to the University Hospital Centre Zagreb in March 2020 for bilateral visual field defects and headaches due to prolactinoma. In 2017, he had a transsphenoidal resectio...

Introduction: Cushing disease (CD) is the leading cause of endogenous hypercortisolism, caused by a pituitary tumor that produces ACTH. Treatment modalities include transsphenoidal selective adenomectomy (TSA), pharmacological therapy, radiotherapy (RT), and bilateral adrenalectomy (BA). The goal of our study was to analyze the outcomes of Cushing disease treatment in UHC Zagreb.Method: This retrospective study comprised 64 patients with CD (51 (80% wome...

Background: Pituitary surgery is the primary therapy for Cushing’s disease (CD). Basal cortisol level (BCL) is measured postoperatively to evaluate the immediate efficacy of surgical treatment, but no definitive cut-off value has yet been determined as reliable. Our pituitary-dedicated centre uses an arbitrary BCL less than 50 nmol/l as expected early remission marker, identifying all patients with higher BCL as a risk group for early surgical failure.<p class="abstex...